You are right. Values from Extension:BlueSpiceConfigManager take precedence over the ones set in LocalSettings.php.
Try to wrap your settings into a $wgExtensionFunctions callback like this:
$GLOBALS['wgExtensionFunctions'][] = static function () {
$GLOBALS['wgPluggableAuth_EnableAutoLogin'] = true;
// Clear out whatever is set by BlueSpiceConfigManager
$GLOBALS['wgPluggableAuth_Config'] = [];
$GLOBALS['wgPluggableAuth_Config']['Log In (MyDomain)'] = [
'plugin' => 'LDAPAuthentication2',
'data' => [
'domain' => 'my.domain.com'
]
];
};
It should make sure your settings are being evaluated after Extension:BlueSpiceConfigManager. Therefore overwriting them.